AMINOGLYCOSIDES-
RENAL DOSING
Guidelines
(modified) of Sarubbi and Hull.
The first dose should be a modified loading dose equal
to the maintenance dose in a subject with normal renal function: Loading dose: 1.5-2.0 mg/kg (gentamicin,
netilmicin, sisomicin, tobramycin).
Loading dose: 5-7.5 mg/kg (amikacin, kanamycin, streptomycin).
The left column represents the creatinine clearance in
mL/min; the three right columns show percent of initial dose at given dosing
interval :
|
Cr
Cl |
q8h |
q12h |
q24h |
|
90 |
84% |
|
|
|
80 |
80 |
91% |
|
|
70 |
76
|
88 |
|
|
60 |
71
|
84 |
|
|
50 |
65
|
79 |
|
|
40 |
|
72
|
92% |
|
30 |
|
63
|
86 |
|
25 |
|
57
|
81 |
|
20 |
|
50
|
75 |
|
17 |
|
46
|
70 |
|
15 |
|
42
|
67 |
|
12 |
|
|
61 |
|
10 |
|
|
56 |
|
7 |
|
|
47 |
|
5 |
|
|
41 |
|
2 |
|
|
30 |
|
0 |
|
|
21 |
Hemodialysis: 1/2 initial dose as a supplement at the
end of dialysis
CAPD: 1/2 initial dose every 48 hr
The maintenance dose should be increased by
approximately 40% in morbidly obese patients.